CV – Dr. Francisco Cubillos

EDUCATION, ACADEMIC AND PROFESSIONAL EXPERIENCE, including students and doctoral training, honors and awards, editorial or advisory committees).

EDUCATION

2007 Molecular Engineering Biotechnology B.Sc degree, University of Chile.

2008 Master in Microbiology University of Chile, Yeast Population Genetics, Advisor: Claudio Martínez

2010 PhD in Genetics University of Nottingham, 2010, Multi-parent populations in yeast, Advisor: Prof Ed Louis

2013 Postdoctoral Fellow INRA-Versailles, 2013, Natural variation in non-coding regions in Arabidopsis thaliana, Advisor: Olivier Loudet

APPOINTMENTS (2015-2022)

May 2013 – to present. Associate Researcher at Universidad de Santiago de Chile, Chile

2016. Young investigator of the Millennium Nucleus for Fungal Integrative and Synthetic Biology

2017 – to date. Associate Researcher Millenium Institute for Integrative Biology.

2020-2022. President of the Chilean Genetics Society

2022 – to date. Associate Researcher Millenium Nucleus LiLi

POSTDOCTORAL SUPERVISION (2015-2022)

Current Postdocts Members

– Dr Pablo Villarreal. FONDECYT 2020-2023

– Dra Jennifer Molinet, FONDECYT 2020-2023

– Dra Macarena Araya, iBio 2021-2022.

– Dr Luis Saona, Núcleo LiLi. 2022-2023

– Dr Felipe Muñoz, FONDECYT 2022-2025

Former Postdoc Members

– Dr Carlos Villarroel, FONDECYT 2017-2020

– Dr Wladimir Mardones, FONDECYT 2019-2022

MASTER THESIS SUPERVISION (2015-2022)

2014-2016 Mara Cuevas. M. Sc. ‘Allelic Variant Identification in S. cerevisiae with biotechnological interest for the wine industry’. Biological Sciences Faculty. Universidad Andrés Bello.

2018-2020. Leonor Alvarado. M. Sc in Conservation, Universidad Bernardo O’Higgins. 2020.

UNDERGRADUATE THESIS DIRECTION (2015 – 2022)

Past graduated students: 21

Current students: 9

Ph.D THESIS SUPERVISION (2015 – 2022)

Current students:

– Franco Vega, 5th year, Biotechnology Ph.D., Universidad de Santiago de Chile

– Tomas Peña, 3rd year, Biotechnology Ph.D., Universidad de Santiago de Chile

– Vasni Zavaleta, 3rd year, Biotechnology Ph.D., Universidad de Santiago de Chile

– Pablo Quintrel, 3rd year, Microbiology Ph.D., Universidad de Santiago de Chile

– Chrisitan Oporto, 2nd year, Microbiology Ph.D., Universidad de Santiago de Chile

– Agustin Cofré, 2nd year, Biotechnology Ph.D., Universidad de Santiago de Chile

HONORS AND AWARDS (2015-2022)

2021. TWAs Young Investigator

2020. EMBO Global Investigator

2016. Beca Santander for internship in Jose Manuel Guillamon’s laboratory, Valencia, Spain.

GRANTS as PI (2015-2022)

2022 – 2026. FONDECYT Regular 1220026 ‘Genomic and transcriptional profiling of fermentative vigor in laboratory lager yeast hybrids.’. Investigador Principal.

2022 – 2025. Research Grant Millennium Nucelus LiLi.

2021-2025. EMBO Global Investigator. Phylogenomic studies in ethanol-tolerant yeast from Patagonia. Principal Investigator.

2020 – 2022. Networking Grant CONICYT-PCI REDES for International Scientific Cooperation Universidad de Santiago de Chile – University of Madison Wisconsin – TU Delft. ‘The SynVAR Collaborative Network: Yeast genetics for Synthetic Biology and Natural Variation advances in

native Patagonian yeasts’. Principal Investigator.

2019 – 2022. Research Grant for International Scientific Cooperation ECOS/CONICYT C18B03 ‘Genomic and physiological Characterization of ethanol-producing yeast populations from Patagonia’. Principal Researcher.

2018 – 2020. FIC Región de los Rios. ‘Hacia la denominación de origen de la cerveza de Los Ríos: descubriendo una levadura nativa’. Co-Researcher

2018 – 2022. FONDECYT Regular 1180161 ‘Decoding the genomic and phenomic complexity of the cryotolerant yeast Saccharomyces eubayanus’. Principal Investigator.

2018 – to date. Millennium Institute for Integrative Systems and Synthetic Biology (MIISSB). Associate Researcher.

2016-2017. Research Grant Millennium Nucleus in Synthetic Fungi Biology MNFISB. Associate Researcher.

2017. Grant Proyectos Extraordinarios USACH 021771CR_CONT ‘Genetic and phenotypic variability in S. cerevisiae natural populations of industrial interest’.

2016 – 2017. PCI-Conicyt. Redes 150077. Networking Grant for International Scientific Cooperation Universidad de Santiago de Chile – INRA Montpellier, France with Prof Sylvie Dequin. ‘Applied yeast genetics for high quality food products’.

2014 – 2017. FONDECYT 11140097. Research Grant FONDECYT de Iniciación ‘Quantitative genetic analysis of the response to mycotoxins in yeast’.

2013 – 2016. ECOS-CONICYT CB1302. Research Grant for International Scientific Cooperation ECOS/CONICYT 2013 ‘Identification of allelic variants underlying Nitrogen Metabolism in yeast through an integrative BS-RNA seq approach’ together with Dr. Gianni Liti, IRCAN, France.

2013 – 2015. CONICYT-PAI 82130010: Research Returning Grant ‘Study of the regulatory variants underlying natural diversity in Saccharomyces cerevisiae’ Program ‘Apoyo al Retorno de Investigadores/as desde el Extranjero – Convocatoria 2012’.

GRANTS as co-PI

2020-2022. FIC Región de los Rios-Chile. Supporting economic re-activation of the brewing Industry in the Rios Region. Co-researcher.

2017-2020 INACH Regular Project RT_09_16 to Dr. Claudio Saez. ‘Biochemical and molecular responses disclose mechanisms of Antarctic macroalgae to thrive under Climate Change’. Co-PI

2016 ICM – Millennium Nucleus MN-FISB. Research Grant Millennium Nucleus in Synthetic Fungi Biology. Young Researcher. 2016.

2015-2019. FONDECYT 1150522. Research Grant FONDECYT Regular to Dr. Claudio Martínez. ‘Identification of natural genetic variants underlying nitrogen assimilation diversity in yeast’. Co-PI

2013-2015. Fic Gore Atacama 33 03 248 Establishment of sustainable systems for process control Pajarete Wine production in the province of Huasco to strengthen their local identity to Angélica Ganga. Co-PI

OUTREACH ACTIVITIES

During the Millenium Institute Dr Cubillos has developed a series of outreach activities with brewers, teaching them about yeast microbiology and bacteria spoilage in the brewery environment. Cubillos organized over four events, involving more than 300 beer producers across different cities in the country.

FORMAL COLLABORATION NETWORKS

Dr Cubillos has a series of international collaborations, mostly within Europe and USA. Among other, Dr Cubillos actively collaborates with Dr Gianni Liti (IRCAN-France) through an ECOS – CONICYT GRANT and Dr. Gilles Fischer, fundend by another ECOS-CONICYT Grant. Moreover, recently Dr Cubillos got another international grant awarded to collaborate beer yeast specialist from the Nethederlands and US. Dr Cubillos also collaborates with Dr Amparo Querol from IATA – Valencia with whom he has been collaborating for the past years in Spain. Similarly, Dr Cubillos has a series of informal collaborations with teams in Finland (Dr Brian Gibson, VTT Technical Research Centre Espoo), Dr Rike Stelkens (Stockholm University, Sweden), Dr Diego Libkind (Universidad Nacional del Comahue, Argentina), Dr Duncan Greig (UCL, UK) and Dr Jonas Warringer (Gothenburg University, Sweden).

PUBLICATIONS

Sánchez, D. A., Díaz-Robles, L. A., Cubillos, F., Gómez, J., Reyes, A., Vallejo, F., & Pino-Cortés, E. (2022). Drying process study of hydrothermal carbonized biomass. Drying Technology, 40(2), 273-283.

Mozzachiodi, S., Bai, F. Y., Baldrian, P., Bell, G., Boundy?Mills, K., Buzzini, P., … & Boynton, P. (2022). Yeasts from temperate forests. Yeast, 39(1-2), 4-24.

Villarreal, P., Quintrel, P. A., Olivares?Muñoz, S., Ruiz, J. J., Nespolo, R. F., & Cubillos, F. A. (2022). Identification of new ethanol?tolerant yeast strains with fermentation potential from central Patagonia. Yeast, 39(1-2), 128-140.

Pino-Cortés, E., Carrasco, S., Díaz-Robles, L. A., Cubillos, F., Vallejo, F., Cereceda-Balic, F., & Fu, J. S. (2022). Emission inventory processing of biomass burning from a global dataset for air quality modeling. Air Quality, Atmosphere & Health, 15(4), 721-729.

Vallejo, F., Diaz-Robles, L. A., Poblete, J., & Cubillos, F. (2022). Experimental study and validation of a kinetic scheme for hydrothermal carbonization reactions. Biofuels, 13(4), 461-466.

Vaishnav, E. D., de Boer, C. G., Molinet, J., Yassour, M., Fan, L., Adiconis, X., … & Regev, A. (2022). The evolution, evolvability and engineering of gene regulatory DNA. Nature, 603(7901), 455-463.

Mardones, W., Villarroel, C. A., Abarca, V., Urbina, K., Pena, T. A., Molinet, J., … & Cubillos, F. A. (2022). Rapid selection response to ethanol in Saccharomyces eubayanus emulates the domestication process under brewing conditions. Microbial biotechnology, 15(3), 967-984.

Olguín, V., Durán, A., Las-Heras, M., Rubilar, J. C., Cubillos, F. A., Olguín, P., & Klein, A. D. (2022). Genetic Background Matters: Population-based Studies in Model Organisms for Translational Research.

Molinet, J., Urbina, K., Villegas, C., Abarca, V., Oporto, C. I., Villarreal, P., … & Cubillos, F. A. (2022). A Saccharomyces eubayanus haploid resource for research studies. Scientific reports, 12(1), 1-16.

Villarroel, C. A., González-González, A., Alvarez-Baca, J. K., Villarreal, P., Ballesteros, G. I., Figueroa, C. C., … & Ramírez, C. C. (2022). Genome sequencing of a predominant clonal lineage of the grain aphid Sitobion avenae. Insect Biochemistry and Molecular Biology, 143, 103742.

Pino-Cortés, E., Díaz-Robles, L. A., Cubillos, F., Cereceda-Balic, F., Santander, R., Fu, J. S., … & Acosta, J. (2021). The black carbon dispersion in the Southern Hemisphere and its transport and fate to Antarctica, an Anthropocene evidence for climate change policies. Science of the Total Environment, 778, 146242.

Pérez-Torrado, R., & Cubillos, F. A. (2021). New Advances in Genetic Studies to Understand Yeast Adaptation to Extreme and Fermentative Environments. Frontiers in Genetics, 336.

Vaishnav, E. D., de Boer, C. G., Yassour, M., Molinet, J., Fan, L., Adiconis, X., … & Regev, A. (2021). A comprehensive fitness landscape model reveals the evolutionary history and future evolvability of eukaryotic cis-regulatory DNA sequences. bioRxiv.

Hernández, J., Tapia, J., Dides, M., & Cubillos, F. (2021). ON LEACHING OF RARE EARTH ELEMENTS FROM A DAVIDITE ORE OF THE III REGION OF CHILE. Journal of Chemical Technology and Metallurgy, 56(1), 247-254.

Murillo, H. A., Díaz-Robles, L. A., Santander, R. E., & Cubillos, F. A. (2021). Conversion of residual oat husk and pine sawdust by co-hydrothermal carbonization towards biofuel production for pellet stoves. Industrial Crops and Products, 174, 114219.

Cerda, A., Rivera, M., Armijo, G., Ibarra-Henriquez, C., Reyes, J., Blázquez-Sánchez, P., … & Gutiérrez, R. A. (2021). A One-Step open RT-qPCR for SARS-CoV-2 detection. medRxiv.

Corvalán, C., Espinoza Pérez, A. T., Díaz?Robles, L. A., Cubillos, F., Vallejo, F., Gómez, J., … & Meriño, J. F. (2021). Life cycle assessment for hydrothermal carbonization of urban organic solid waste in comparison with gasification process: A case study of Southern Chile. Environmental Progress & Sustainable Energy, 40(6), e13688.

Del Campo, A., Salamanca, C., Fajardo, A., Díaz-Castro, F., Bustos, C., Calfío, C., … & Rojo, L. E. (2021). Anthocyanins from Aristotelia chilensis Prevent Olanzapine-Induced Hepatic-Lipid Accumulation but Not Insulin Resistance in Skeletal Muscle Cells. Molecules, 26(20), 6149.

Villarroel, C. A., Bastías, M., Canessa, P., & Cubillos, F. A. (2021). Uncovering divergence in gene expression regulation in the adaptation of yeast to nitrogen scarcity. Msystems, 6(4), e00466-21.

Murillo, H. A., Díaz-Robles, L. A., Santander, R. E., & Cubillos, F. A. (2021). Conversion of residual biomass into valuable biofuels by co-hydrothermal carbonization for utilization in household pellet stoves. Biomass and Bioenergy, 151, 106153.

Pino-Cortés, E., Carrasco, S., Díaz-Robles, L. A., Cubillos, F., & Cereceda-Balic, F. (2020). Black and organic carbon fractions in fine particulate matter by sectors in the South Hemisphere emissions for decision-making on climate change and health effects. Environmental Science and Pollution Research, 27(30), 38344-38352.

Vallejo, F., Díaz-Robles, L. A., Vega, R., & Cubillos, F. (2020). A novel approach for prediction of mass yield and higher calorific value of hydrothermal carbonization by a robust multilinear model and regression trees. Journal of the Energy Institute, 93(4), 1755-1762.

Mardones, W., Villarroel, C. A., Krogerus, K., Tapia, S. M., Urbina, K., Oporto, C. I., … & Cubillos, F. A. (2020). Molecular profiling of beer wort fermentation diversity across natural Saccharomyces eubayanus isolates. Microbial Biotechnology, 13(4), 1012-1025.

Mandakovic, D., Pulgar, R., Maldonado, J., Mardones, W., González, M., Cubillos, F. A., & Cambiazo, V. (2020). Fungal diversity analysis of grape musts from central valley-Chile and characterization of potential new starter cultures. Microorganisms, 8(6), 956.

Gómez, J., Corsi, G., Pino-Cortés, E., Díaz-Robles, L. A., Campos, V., Cubillos, F., … & Monedero, E. (2020). Modeling and simulation of a continuous biomass hydrothermal carbonization process. Chemical Engineering Communications, 207(6), 751-768.

Nespolo, R. F., Solano?Iguaran, J. J., Paleo?López, R., Quintero?Galvis, J. F., Cubillos, F. A., & Bozinovic, F. (2020). Performance, genomic rearrangements, and signatures of adaptive evolution: lessons from fermentative yeasts. Ecology and evolution, 10(12), 5240-5250.

Urbina, K., Villarreal, P., Nespolo, R. F., Salazar, R., Santander, R., & Cubillos, F. A. (2020). Volatile compound screening using HS-SPME-GC/MS on Saccharomyces eubayanus strains under low-temperature pilsner wort fermentation. Microorganisms, 8(5), 755.

Nespolo, R. F., Villarroel, C. A., Oporto, C. I., Tapia, S. M., Vega-Macaya, F., Urbina, K., … & Cubillos, F. A. (2020). An Out-of-Patagonia migration explains the worldwide diversity and distribution of Saccharomyces eubayanus lineages. PLoS genetics, 16(5), e1008777.

Pino-Cortés, E., Díaz-Robles, L. A., Campos, V., Vallejo, F., Cubillos, F., Gómez, J., … & Figueroa, J. (2020). Effect of socioeconomic status on the relationship between short-term exposure to PM2. 5 and cardiorespiratory mortality and morbidity in a megacity: the case of Santiago de Chile. Air Quality, Atmosphere & Health, 13(5), 509-517.

Devia, J., Bastías, C., Kessi-Pérez, E. I., Villarroel, C. A., De Chiara, M., Cubillos, F. A., … & Salinas, F. (2020). Transcriptional activity and protein levels of horizontally acquired genes in yeast reveal hallmarks of adaptation to fermentative environments. Frontiers in genetics, 11, 293.

Carrasco, S., Silva, J., Pino-Cortés, E., Gómez, J., Vallejo, F., Díaz-Robles, L., … & Hoekman, K. (2020). Experimental study on hydrothermal carbonization of lignocellulosic biomass with magnesium chloride for solid fuel production. Processes, 8(4), 444.

Pino-Cortés, E., Montalvo, S., Huiliñir, C., Cubillos, F., & Gacitúa, J. (2020). Characteristics and treatment of wastewater from the mercaptan oxidation process: a comprehensive review. Processes, 8(4), 425.

Libkind, D., Peris, D., Cubillos, F. A., Steenwyk, J. L., Opulente, D. A., Langdon, Q. K., … & Hittinger, C. T. (2020). Into the wild: new yeast genomes from natural environments and new tools for their analysis. FEMS yeast research, 20(2), foaa008.

Mardones, W., Villarroel, C. A., Abarca, V., Urbina, K., Peña, T. A., Molinet, J., … & Cubillos, F. A. (2020). Rapid selection response to ethanol in S. eubayanus emulates the domestication process under brewing conditions. bioRxiv.

Molinet, J., & Cubillos, F. A. (2020). Wild yeast for the future: exploring the use of wild strains for wine and beer fermentation. Frontiers in Genetics, 1281.

Vallejoa, F., Díaz-Roblesa, L., Vegaa, R., Cubillosa, F., Espinozab, A. P., Pinillaa, F., & Pino-Cortésd, E. (2020). An experimental study for municipal organic waste and sludge treated by hydrothermal carbonization. CHEMICAL ENGINEERING, 81.

Vallejoa, F., Díaz-Roblesa, L., Cubillosa, F., & Perez, A. (2020). Valorization of municipal solid waste using hydrothermal carbonization and gasification: A review. CHEMICAL ENGINEERING, 81.

Monedero, E., Lapuerta, M., Pazo, A., Díaz-Robles, L. A., Pino-Cortés, E., Campos, V., … & Gómez, J. (2019). Effect of hydrothermal carbonization on the properties, devolatilization, and combustion kinetics of Chilean biomass residues. Biomass and Bioenergy, 130, 105387.

Molinet, J., Cubillos, F. A., Salinas, F., Liti, G., & Martínez, C. (2019). Genetic variants of TORC1 signaling pathway affect nitrogen consumption in Saccharomyces cerevisiae during alcoholic fermentation. PloS one, 14(7), e0220515.

Oporto, C. I., Villarroel, C. A., Tapia, S. M., García, V., & Cubillos, F. A. (2019). Distinct transcriptional changes in response to patulin underlie toxin biosorption differences in Saccharomyces cerevisiae. Toxins, 11(7), 400.

Cubillos, F. A., Gibson, B., Grijalva?Vallejos, N., Krogerus, K., & Nikulin, J. (2019). Bioprospecting for brewers: Exploiting natural diversity for naturally diverse beers. Yeast, 36(6), 383-398.

Pino-Cortés, E., Díaz-Robles, L. A., Cubillos, F., Cereceda-Balic, F., & HIDALGO, S. R. C. (2019). Emission inventory of biomass burning from GFASV3 using SMOKE, the case of 2014. In Proceedings of the Air and Waste Management Association’s Annual Conference and Exhibition, AWMA (Vol. 2019).

Vallejo, F., Diaz-Robles, L. A., Cubillos, F., Vega, R., Pino-Cortés, E., Carrasco, S., & Gomez, J. (2019). Performance evaluation of biomass blends with additives treated by hydrothermal carbonization. CHEMICAL ENGINEERING, 76.

Nespolo, R. F., Villarroel, C. A., Oporto, C. I., Tapia, S. M., Vega, F., Urbina, K., … & Cubillos, F. A. (2019). An Out-of-Patagonia dispersal explains most of the worldwide genetic distribution in Saccharomyces eubayanus. bioRxiv, 709253.

Tapia, S. M., Cuevas, M., Abarca, V., Delgado, V., Rojas, V., García, V., … & Cubillos, F. A. (2018). GPD1 and ADH3 natural variants underlie glycerol yield differences in wine fermentation. Frontiers in microbiology, 9, 1460.

Brice, C., Cubillos, F. A., Dequin, S., Camarasa, C., & Martínez, C. (2018). Adaptability of the Saccharomyces cerevisiae yeasts to wine fermentation conditions relies on their strong ability to consume nitrogen. PLoS One, 13(2), e0192383.

Molinet-Parada, J. N., Cubillos, F. A., Salinas, F., Liti, G., & Martínez, C. (2018). Genetic variants of the TORC1 signaling pathway affect nitrogen consumption in Saccharomyces cerevisiae during the alcoholic fermentation.

Torres, G., Barbosa, K. A., & Cubillos, F. (2017, October). Non-linear control design to direct rotary dryer. In 2017 CHILEAN Conference on Electrical, Electronics Engineering, Information and Communication Technologies (CHILECON) (pp. 1-6). IEEE.

Quispe, X., Tapia, S. M., Villarroel, C., Oporto, C., Abarca, V., García, V., … & Cubillos, F. A. (2017). Genetic basis of mycotoxin susceptibility differences between budding yeast isolates. Scientific reports, 7(1), 1-11.

Cubillos, F. A., Brice, C., Molinet, J., Tisné, S., Abarca, V., Tapia, S. M., … & Martínez, C. (2017). Identification of nitrogen consumption genetic variants in yeast through QTL mapping and bulk segregant RNA-Seq analyses. G3: Genes, Genomes, Genetics, 7(6), 1693-1705.

Godoy, L., Silva-Moreno, E., Mardones, W., Guzman, D., Cubillos, F. A., & Ganga, A. (2017). Genomics perspectives on metabolism, survival strategies, and biotechnological applications of Brettanomyces bruxellensis LAMAP2480. Microbial Physiology, 27(3), 147-158.

Thompson, D. A., & Cubillos, F. A. (2017). Natural gene expression variation studies in yeast. Yeast, 34(1), 3-17.

Salinas, F., De Boer, C. G., Abarca, V., García, V., Cuevas, M., Araos, S., … & Cubillos, F. A. (2016). Natural variation in non-coding regions underlying phenotypic diversity in budding yeast. Scientific reports, 6(1), 1-13.

Cubillos, F. A. (2016). Exploiting budding yeast natural variation for industrial processes. Current genetics, 62(4), 745-751.

Vásquez, J., Reyes, A., Mahn, A., & Cubillos, F. (2016). Experimental evaluation of fuzzy control solar drying with thermal energy storage system. Drying Technology, 34(13), 1558-1566.

Núñez, C. G., Peña, M., Cubillos, F., & Solorza, H. (2016). We are all together: the closing of the rural school from the children’s perspective. Educação e Pesquisa, 42, 953-967.

Núñez, C. G., Peña, M., Cubillos, F., & Solorza, H. (2016). Estamos todos juntos: el cierre de la Escuela Rural desde la perspectiva de los niños. Educação e Pesquisa, 42, 953-967.

Kessi-Pérez, E. I., Araos, S., García, V., Salinas, F., Abarca, V., Larrondo, L. F., … & Cubillos, F. A. (2016). RIM15 antagonistic pleiotropy is responsible for differences in fermentation and stress response kinetics in budding yeast. FEMS yeast research, 16(3), fow021.

Pino-Cortés, E., Díaz-Robles, L. A., Cubillos, F., Fu, J. S., & Vergara-Fernández, A. (2015). Sensitivity analysis of biodiesel blends on Benzo [a] pyrene and main emissions using MOVES: A case study in Temuco, Chile. Science of The Total Environment, 537, 352-359.

Acuna, G., Cubillos, F., Araya, B., Segovia, G., Pérez, C., Curilem, M., & Huanquilef, C. (2015, October). NARX neural network model for predicting availability of a heavy duty mining equipment. In 2015 Latin America Congress on Computational Intelligence (LA-CCI) (pp. 1-5). IEEE.

Curilem, M., Huanquilef, C., Acuna, G., Cubillos, F., Araya, B., Segovia, G., & Pérez, C. (2015, October). Prediction of the criticality of a heavy duty mining equipment. In 2015 Latin America Congress on Computational Intelligence (LA-CCI) (pp. 1-5). IEEE.

Garcia, V., Scovacricchi, E., Cubillos, F. A., & Martinez, C. (2015, September). Study of effectors proteins of Campylobacter jejuni using yeast as model. In YEAST (Vol. 32, pp. S178-S178). 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: WILEY-BLACKWELL.

Robles, L. A. D., Figueroa, C., CORTES, E. P., Cubillos, F., Vergara-Fernández, A., & Cereceda-Balic, F. (2015). Source apportionment of PAHs in Temuco Chile using receptor modeling and high-volume PM2. 5 sampling. In 108th Air and Waste Management Association Annual Conference and Exhibition-Connecting the Dots: Environmental Quality to Climate, ACE 2015 (pp. 349-354). Air and Waste Management Association.

Núñez, C. G., Cubillos, F., & Solorza, H. (2015). El cierre de las escuelas rurales en Chile: la escuela desplazada al no lugar. Arquitectonics: Mind, Land & Society, (27), 107-113.

Brice, C., Cubillos, F., Dequin, S., Camarasa, C., & Martinez, C. (2015). The impact of the adaptation to different nutritional environments reveals diverse strategies in nitrogen consumption between Saccharomyces cerevisiae strains.

Acuña, G., Curilem, M., Araya, B., Cubillos, F., Miranda, R., & Garrido, F. (2014, November). Predictive models applied to heavy duty equipment management. In Mexican International Conference on Artificial Intelligence (pp. 198-205). Springer, Cham.

Cubillos, F. A., Stegle, O., Grondin, C., Canut, M., Tisné, S., Gy, I., & Loudet, O. (2014). Extensive cis-regulatory variation robust to environmental perturbation in Arabidopsis. The Plant Cell, 26(11), 4298-4310.

Salazar, J. L., Valdés-González, H., Vyhmesiter, E., & Cubillos, F. (2014). Model predictive control of semiautogenous mills (sag). Minerals Engineering, 64, 92-96.

Reyes, A., Cubillos, F., Mahn, A., & Vásquez, J. (2014). Dehydration of agro products in a hybrid solar dryer controlled through a fuzzy logic system. International Journal of Modern Nonlinear Theory and Application, 2014.

Navia, D., Sarabia, D., Gutiérrez, G., Cubillos, F., & de Prada, C. (2014). A comparison between two methods of stochastic optimization for a dynamic hydrogen consuming plant. Computers & Chemical Engineering, 63, 219-233.

Reyes, A., Cubillos, F., Mahn, A., & Vásquez, J. (2014, March). Control system in a hybrid solar dryer. In 2014 5th International Renewable Energy Congress (IREC) (pp. 1-5). IEEE.

Jara, M., Cubillos, F. A., García, V., Salinas, F., Aguilera, O., Liti, G., & Martínez, C. (2014). Mapping genetic variants underlying differences in the central nitrogen metabolism in fermenter yeasts. PLoS One, 9(1), e86533.

Eckwahl, M. (Ed.). (2014). Investigations in Yeast Functional Genomics and Molecular Biology. CRC Press.

Menacho, J., Rodríguez, J., Cubillos, F., & Gomez, C. (2014). A comprehensive bubble life model for conventional flotation. In 27th International Mineral Processing Congress, IMPC 2014. Gecamin.

Acuña, G., Curilem, M., & Cubillos, F. (2014). Desarrollo de un sensor virtual basado en modelo NARMAX y máquina de vectores de soporte para molienda semiautógena. Revista Iberoamericana de Automática e Informática Industrial RIAI, 11(1), 109-116.

Liti, G., Ba, A. N. N., Blythe, M., Müller, C. A., Bergström, A., Cubillos, F. A., … & Nieduszynski, C. A. (2013). High quality de novo sequencing and assembly of the Saccharomyces arboricolus genome. BMC genomics, 14(1), 1-14.

Acuña, G., González, J., Curilem, M., & Cubillos, F. (2013). A SVM gray-box model for a solid substrate fermentation process. Chemical Engineering Transactions, 35, 961-966.

Reyes, A., Mahn, A., Cubillos, F., & Huenulaf, P. (2013). Mushroom dehydration in a hybrid-solar dryer. Energy conversion and management, 70, 31-39.

Perez, J., Soto, I., Alfaro, M., Cubillos, F., & Xiao, P. (2013, April). Real-Time Modeling in Pervasive Mining. In The Eighth International Conference on Digital Telecommunications (pp. 60-66).

NÚÑEZ, C. G., SOLÍS, C., SOTO, R., CUBILLOS, F., & SOLORZA, H. (2013). La escuela da vida: el cierre de escuelas rurales en Chile según las comunidades. Sociedad Hoy, (24), 49-54.

Perez, J., Soto, I., Cubillos, F., Sun, L., & Liu, K. (2013). Real-time identification and modelling in pervasive mining.

Henriquez-Vargas, L., Bubnovich, V., Donoso-Garcia, P., & Cubillos, F. (2013). Modeling, simulation, and control for a continuous flow porous media burner. Journal of Porous Media, 16(2).

Zörgö, E., Gjuvsland, A., Cubillos, F. A., Louis, E. J., Liti, G., Blomberg, A., … & Warringer, J. (2012). Life history shapes trait heredity by accumulation of loss-of-function alleles in yeast. Molecular biology and evolution, 29(7), 1781-1789.

Vyhmeister, E., Estay, H., Romero, J., & Cubillos, F. (2012). Simulation and process optimization of a membrane-based dense gas extraction using hollow fiber contactors. Chemical Engineering Communications, 199(5), 644-657.

Cubillos, F. A., Vyhmeister, E., Acuña, G., & Alvarez, P. I. (2011). Rotary dryer control using a grey-box neural model scheme. Drying Technology, 29(15), 1820-1827.

Curilem, M., Acuña, G., Cubillos, F., & Vyhmeister, E. (2011). Neural networks and support vector machine models applied to energy consumption optimization in semiautogeneous grinding. Chemical Engineering Transactions, 25, 761-766.

Henríquez-Vargas, L., Bubnovich, V., & Cubillos, F. (2011). Dynamic optimization of porous media combustor using a greybox neural model and NMPC technique. In Computer Aided Chemical Engineering (Vol. 29, pp. 683-687). Elsevier.

Henríquez, L., Bubnovich, V., & Cubillos, F. (2010). Dynamic Optimization of Porous Media Combuster Through Flame Positioning. Chemical Engineering Transactions, 21, 961-966.

Navia, D., De Prada, C., & Cubillos, F. (2010). Heat integration and optimal HEN design applied to a gas pipeline/power generation system. In 19th International Congress of Chemical and Process Engineering, CHISA 2010 and 7th European Congress of Chemical Engineering, ECCE-7.

Navia, D., de Prada, C., Gutierreza, G., & Cubillos, F. (2010). Synthesis of Multiperiod Heat Exchanger Networks Comprising Different Heat Exchanger Types. 20th ESCAPE.

Salazar, J. L., Valdés-González, H., & Cubillos, F. (2010). Advanced Simulation for Semi-Autogenous Mill Systems: A Simplified Models Approach. In Dynamic Modelling. IntechOpen.

Cubillos, F. A., Vasquez, C., Faugeron, S., Ganga, A., & Martínez, C. (2009). Self-fertilization is the main sexual reproduction mechanism in native wine yeast populations. FEMS microbiology ecology, 67(1), 162-170.

Salazar, J. L., Magne, L., Acuna, G., & Cubillos, F. (2009). Dynamic modelling and simulation of semi-autogenous mills. Minerals Engineering, 22(1), 70-77.

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