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CV Dr. Paulo Canessa

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canessa150-01

 

Paulo Canessa

EDUCATION, ACADEMIC AND PROFESSIONAL EXPERIENCE

 

EDUCATION

2003                Bachelors degree in Biological Sciences, PUC

2007                Masters degree in Biological Sciences, PUC

2009                Ph.D. in Biological Sciences, Molecular Genetics and Microbiology, PUC. Advisor: Dr. Rafael Vicuña.

2010-2015      Postdoc, Pontificia Universidad Católica de Chile. Advisor: Dr. Luis Larrondo.

 

APPOINTMENTS

2022-present   Director, Center for Plant Biotechnology, Universidad Andres Bello, UNAB,

2022-present   Associate Professor at Universidad Andres Bello, UNAB, Chile

2016-2021      Assistant Professor at Universidad Andres Bello, UNAB, Chile

POSTDOCS SUPERVISION

2019–present  Consuelo Olivares
2020-present   Mario Agurto

PhD THESIS SUPERVISION

Current           Gabriel Perez; 
Current           Kamila Fernandez
Current           Gustavo Hoppe
2016-2020      Marlene Henriquez

MASTER THESIS SUPERVISION

Current           Daniela Lopez Leiva. 
2021                Jaime Naranjo
2019                Esteban Vasquez

UNDERGRADUATE THESIS DIRECTION

Current           Consuelo Inostroza,
Current           Rocio Fontt
Current           Nicolas Arias
2020                Daniela Lopez,
2020                Jaime Naranjo; 
2019                Gabriel Perez; 
2018                Rosario Guivernau
2015                Hanna Muller 
2013                Ignacio Retamal
 

HONORS AND AWARDS (selected)

2014                Fondecyt-Initiation grant. Selected first within the Study Section
2010                Postdoctoral Fellow (October 2010) FONDECYT-Chile. Selected in first position within BIO 3 study section
2010                International Fellow Award to “young promising scientists” by The Bibliotheca Alexandrina and The Academy of Sciences for the  Developing countries (TWAS)
2007                Financial Aid Awardee given by the United States Department of Energy (DOE) and the Genetics Society of America to assist to the Postia placenta genome annotation jamboree project.
 

INTELLECTUAL PROPERTY (Patents)

Patent application at INAPI-Chile, 3363-2016. “Method for massive screening of controlling substances of phytopathogenic fungi based on genetically modified strains”

GRANTS as PI

2022-2023      The Company of Biologists’ grant for the «Molecular Biosystems» Conference on Eukaryotic Gene Regulation and Functional Genomics, 2023.

2019-2023      Fondecyt-Regular 1190611. “Iron acquisition in Botrytis cinerea: the reductive iron assimilation pathway and the modulation of the fungal pathogenic potential”

2017-2026      Millennium Institute of Integrative Systems and Synthetic Biology 

2014-2017      Fondecyt-Initiation 11140678. «Digging into the light-dependent regulation of a pathogen/host molecular system: understanding the effects of light modulating B. cinerea pathogenesis on A. thaliana«

2013-2014      Research and Development Biotechnological Project (2012.J.18) Financed by the Copec-UC Research Foundation. Aimed to develop Botrytis cinerea new control strategies.

2010-2013      Fondecyt-Postdoc 3110127 (Selected first within the Study Section). “Modulation of Botrytis cinerea virulence factors: evaluating the effect of light and circadian-regulation”.

 

GRANTS as co-PI

2017-2020      Fondecyt-Regular 1171631 “Uncovering plant hormone signaling in nitrate-defense response interaction in tomato”

2017-2019      Iniciativa Científica Milenio (NC120043-Renewal) Millennium Nucleus for Fungal Integrative and Synthetic Biology (FISB)

2014-2016      Young Investigator, Millennium Nucleus for Fungal Integrative and Synthetic Biology

2013-2014      Young Investigator, International Networks between Research Centers ceCIBUC-Chile and the Center for Genomics and Systems Biology, New York University»)

 

PUBLICATIONS

  1. Rojas, V., Salinas, F., Romero, A., Larrondo, L.F., Canessa, P., 2022. Interactions between Core Elements of the Botrytis cinerea Circadian Clock Are Modulated by Light and Different Protein Domains. J Fungi (Basel) 8. https://doi.org/10.3390/jof8050486
  2. Olivares-Yañez, C., Sánchez, E., Pérez-Lara, G., Seguel, A., Camejo, P.Y., Larrondo, L.F., Vidal, E.A., Canessa, P., 2021. A comprehensive transcription factor and DNA-binding motif resource for the construction of gene regulatory networks in Botrytis cinerea and Trichoderma  atroviride. Comput Struct Biotechnol J 19, 6212–6228. https://doi.org/10.1016/j.csbj.2021.11.012
  3. Villarroel, C.A., Bastías, M., Canessa, P., Cubillos, F.A., 2021. Uncovering Divergence in Gene Expression Regulation in the Adaptation of Yeast to Nitrogen Scarcity. mSystems 6, e0046621. https://doi.org/10.1128/mSystems.00466-21
  4. Leiva-Ampuero, A., Agurto, M., Matus, J.T., Hoppe, G., Huidobro, C., Inostroza-Blancheteau, C., Reyes-Díaz, M., Stange, C., Canessa, P., Vega, A., 2020. Salinity impairs photosynthetic capacity and enhances carotenoid-related gene expression and biosynthesis in tomato (Solanum lycopersicum L. cv. Micro-Tom). PeerJ 8, e9742. https://doi.org/10.7717/peerj.9742
  5. Vasquez-Montaño, E., Hoppe, G., Vega, A., Olivares-Yañez, C., Canessa, P., 2020. Defects in the Ferroxidase That Participates in the Reductive Iron Assimilation System Results in Hypervirulence in Botrytis Cinerea. mBio 11. https://doi.org/10.1128/mBio.01379-20
  6. Larrondo, L.F., Canessa, P., 2019. The Clock Keeps on Ticking: Emerging Roles for Circadian Regulation in the Control of Fungal Physiology and Pathogenesis. Curr Top Microbiol Immunol 422, 121–156. https://doi.org/10.1007/82_2018_143
  7. Arraño-Salinas, P., Domínguez-Figueroa, J., Herrera-Vásquez, A., Zavala, D., Medina, J., Vicente-Carbajosa, J., Meneses, C., Canessa, P., Moreno, A.A., Blanco-Herrera, F., 2018. WRKY7, -11 and -17 transcription factors are modulators of the bZIP28 branch of the unfolded protein response during PAMP-triggered immunity in Arabidopsis  thaliana. Plant Sci 277, 242–250. https://doi.org/10.1016/j.plantsci.2018.09.019
  8. Castillo, L., Plaza, V., Larrondo, L.F., Canessa, P., 2017. Recent Advances in the Study of the Plant Pathogenic Fungus Botrytis cinerea and its Interaction with the Environment. Curr Protein Pept Sci 18, 976–989. https://doi.org/10.2174/1389203717666160809160915
  9. Franco, D.L., Canessa, P., Bellora, N., Risau-Gusman, S., Olivares-Yañez, C., Pérez-Lara, R., Libkind, D., Larrondo, L.F., Marpegan, L., 2017. Spontaneous circadian rhythms in a cold-adapted natural isolate of Aureobasidium pullulans. Sci Rep 7, 13837. https://doi.org/10.1038/s41598-017-14085-6
  10. Gaskell, J., Kersten, P., Larrondo, L.F., Canessa, P., Martinez, D., Hibbett, D., Schmoll, M., Kubicek, C.P., Martinez, A.T., Yadav, J., Master, E., Magnuson, J.K., Yaver, D., Berka, R., Lail, K., Chen, C., LaButti, K., Nolan, M., Lipzen, A., Aerts, A., Riley, R., Barry, K., Henrissat, B., Blanchette, R., Grigoriev, I.V., Cullen, D., 2017. Draft genome sequence of a monokaryotic model brown-rot fungus Postia (Rhodonia) placenta SB12. Genom Data 14, 21–23. https://doi.org/10.1016/j.gdata.2017.08.003
  11. Hevia, M.A., Canessa, P., Larrondo, L.F., 2016. Circadian clocks and the regulation of virulence in fungi: Getting up to speed. Semin Cell Dev Biol 57, 147–155. https://doi.org/10.1016/j.semcdb.2016.03.021
  12. Hevia, M.A., Canessa, P., Müller-Esparza, H., Larrondo, L.F., 2015. A circadian oscillator in the fungus Botrytis cinerea regulates virulence when infecting Arabidopsis thaliana. Proc Natl Acad Sci U S A 112, 8744–8749. https://doi.org/10.1073/pnas.1508432112
  13. Montenegro-Montero, A., Canessa, P., Larrondo, L.F., 2015. Around the Fungal Clock: Recent Advances in the Molecular Study of Circadian Clocks in Neurospora and Other Fungi. Adv Genet 92, 107–184. https://doi.org/10.1016/bs.adgen.2015.09.003
  14. Plaza, V., Lagües, Y., Carvajal, M., Pérez-García, L.A., Mora-Montes, H.M., Canessa, P., Larrondo, L.F., Castillo, L., 2015. bcpmr1 encodes a P-type Ca(2+)/Mn(2+)-ATPase mediating cell-wall integrity and virulence in the phytopathogen Botrytis cinerea. Fungal Genet Biol 76, 36–46. https://doi.org/10.1016/j.fgb.2015.01.012
  15. Vega, A., Canessa, P., Hoppe, G., Retamal, I., Moyano, T.C., Canales, J., Gutiérrez, R.A., Rubilar, J., 2015. Transcriptome analysis reveals regulatory networks underlying differential susceptibility to Botrytis cinerea in response to nitrogen availability in  Solanum lycopersicum. Front Plant Sci 6, 911. https://doi.org/10.3389/fpls.2015.00911
  16. Hori, C., Ishida, T., Igarashi, K., Samejima, M., Suzuki, H., Master, E., Ferreira, P., Ruiz-Dueñas, F.J., Held, B., Canessa, P., Larrondo, L.F., Schmoll, M., Druzhinina, I.S., Kubicek, C.P., Gaskell, J.A., Kersten, P., St John, F., Glasner, J., Sabat, G., Splinter BonDurant, S., Syed, K., Yadav, J., Mgbeahuruike, A.C., Kovalchuk, A., Asiegbu, F.O., Lackner, G., Hoffmeister, D., Rencoret, J., Gutiérrez, A., Sun, H., Lindquist, E., Barry, K., Riley, R., Grigoriev, I.V., Henrissat, B., Kües, U., Berka, R.M., Martínez, A.T., Covert, S.F., Blanchette, R.A., Cullen, D., 2014. Analysis of the Phlebiopsis gigantea genome, transcriptome and secretome provides insight into its pioneer colonization strategies of wood. PLoS Genet 10, e1004759. https://doi.org/10.1371/journal.pgen.1004759
  17. Canessa, P., Larrondo, L.F., 2013. Environmental responses and the control of iron homeostasis in fungal systems. Appl Microbiol Biotechnol 97, 939–955. https://doi.org/10.1007/s00253-012-4615-x
  18. Canessa, P., Schumacher, J., Hevia, M.A., Tudzynski, P., Larrondo, L.F., 2013. Assessing the effects of light on differentiation and virulence of the plant pathogen Botrytis cinerea: characterization of the White Collar Complex. PLoS One 8, e84223. https://doi.org/10.1371/journal.pone.0084223
  19. Canessa, P., Muñoz-Guzmán, F., Vicuña, R., Larrondo, L.F., 2012. Characterization of PIR1, a GATA family transcription factor involved in iron responses in the white-rot fungus Phanerochaete chrysosporium. Fungal Genet Biol 49, 626–634. https://doi.org/10.1016/j.fgb.2012.05.013
  20. Fernandez-Fueyo, E., Ruiz-Dueñas, F.J., Ferreira, P., Floudas, D., Hibbett, D.S., Canessa, P., Larrondo, L.F., James, T.Y., Seelenfreund, D., Lobos, S., Polanco, R., Tello, M., Honda, Y., Watanabe, Takahito, Watanabe, Takashi, Ryu, J.S., Kubicek, C.P., Schmoll, M., Gaskell, J., Hammel, K.E., St John, F.J., Vanden Wymelenberg, A., Sabat, G., Splinter BonDurant, S., Syed, K., Yadav, J.S., Doddapaneni, H., Subramanian, V., Lavín, J.L., Oguiza, J.A., Perez, G., Pisabarro, A.G., Ramirez, L., Santoyo, F., Master, E., Coutinho, P.M., Henrissat, B., Lombard, V., Magnuson, J.K., Kües, U., Hori, C., Igarashi, K., Samejima, M., Held, B.W., Barry, K.W., LaButti, K.M., Lapidus, A., Lindquist, E.A., Lucas, S.M., Riley, R., Salamov, A.A., Hoffmeister, D., Schwenk, D., Hadar, Y., Yarden, O., de Vries, R.P., Wiebenga, A., Stenlid, J., Eastwood, D., Grigoriev, I.V., Berka, R.M., Blanchette, R.A., Kersten, P., Martinez, A.T., Vicuna, R., Cullen, D., 2012. Comparative genomics of Ceriporiopsis subvermispora and Phanerochaete chrysosporium provide insight into selective ligninolysis. Proc Natl Acad Sci U S A 109, 5458–5463. https://doi.org/10.1073/pnas.1119912109
  21. Mancilla, R.A., Canessa, P., Manubens, A., Vicuña, R., 2010. Effect of manganese on the secretion of manganese-peroxidase by the basidiomycete Ceriporiopsis subvermispora. Fungal Genet Biol 47, 656–661. https://doi.org/10.1016/j.fgb.2010.04.003
  22. Alvarez, J.M., Canessa, P., Mancilla, R.A., Polanco, R., Santibáñez, P.A., Vicuña, R., 2009. Expression of genes encoding laccase and manganese-dependent peroxidase in the fungus Ceriporiopsis subvermispora is mediated by an ACE1-like copper-fist  transcription factor. Fungal Genet Biol 46, 104–111. https://doi.org/10.1016/j.fgb.2008.10.002
  23. Martinez, D., Challacombe, J., Morgenstern, I., Hibbett, D., Schmoll, M., Kubicek, C.P., Ferreira, P., Ruiz-Duenas, F.J., Martinez, A.T., Kersten, P., Hammel, K.E., Vanden Wymelenberg, A., Gaskell, J., Lindquist, E., Sabat, G., Bondurant, S.S., Larrondo, L.F., Canessa, P., Vicuna, R., Yadav, J., Doddapaneni, H., Subramanian, V., Pisabarro, A.G., Lavín, J.L., Oguiza, J.A., Master, E., Henrissat, B., Coutinho, P.M., Harris, P., Magnuson, J.K., Baker, S.E., Bruno, K., Kenealy, W., Hoegger, P.J., Kües, U., Ramaiya, P., Lucas, S., Salamov, A., Shapiro, H., Tu, H., Chee, C.L., Misra, M., Xie, G., Teter, S., Yaver, D., James, T., Mokrejs, M., Pospisek, M., Grigoriev, I.V., Brettin, T., Rokhsar, D., Berka, R., Cullen, D., 2009. Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion. Proc Natl Acad Sci U S A 106, 1954–1959. https://doi.org/10.1073/pnas.0809575106
  24. Canessa, P., Álvarez, J.M., Polanco, R., Bull, P., Vicuña, R., 2008. The copper-dependent ACE1 transcription factor activates the transcription of the mco1 gene from the basidiomycete Phanerochaete chrysosporium. Microbiology (Reading) 154, 491–499. https://doi.org/10.1099/mic.0.2007/013128-0
  25. Larrondo, L.F., Canessa, P., Melo, F., Polanco, R., Vicuña, R., 2007a. Cloning and characterization of the genes encoding the high-affinity iron-uptake protein complex Fet3/Ftr1 in the basidiomycete Phanerochaete chrysosporium. Microbiology (Reading) 153, 1772–1780. https://doi.org/10.1099/mic.0.2006/003442-0
  26. Larrondo, L.F., Canessa, P., Vicuña, R., Stewart, P., Vanden Wymelenberg, A., Cullen, D., 2007b. Structure and transcriptional impact of divergent repetitive elements inserted within Phanerochaete chrysosporium strain RP-78 genes. Mol Genet Genomics 277, 43–55. https://doi.org/10.1007/s00438-006-0167-z
  27. Manubens, A., Canessa, P., Folch, C., Avila, M., Salas, L., Vicuña, R., 2007. Manganese affects the production of laccase in the basidiomycete Ceriporiopsis subvermispora. FEMS Microbiol Lett 275, 139–145. https://doi.org/10.1111/j.1574-6968.2007.00874.x
  28. Polanco, R., Canessa, P., Rivas, A., Larrondo, L.F., Lobos, S., Vicuña, R., 2006. Cloning and functional characterization of the gene encoding the transcription factor Ace1 in the basidiomycete Phanerochaete chrysosporium. Biol Res 39, 641–648. https://doi.org/10.4067/s0716-97602006000500007
  29. Manubens, A., Avila, M., Canessa, P., Vicuña, R., 2003. Differential regulation of genes encoding manganese peroxidase (MnP) in the basidiomycete Ceriporiopsis subvermispora. Curr Genet 43, 433–438. https://doi.org/10.1007/s00294-003-0410-7
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